Do people with myeloma have an antibody response to the COVID vaccine?

Myeloma have antibody COVID vaccine response ?

Patients who have active chronic lymphocytic leukaemia or multiple myeloma seem to have significantly lower antibody responses to  COVID-19 vaccines than healthy individuals, according to recent reports, with the studies suggesting that both cancer treatment and the cancer itself might be responsible for this. 

An Israeli study found individuals who had leukaemia and myeloma had a greatly lower rate of immune response to the two-dose vaccines from Pfizer and BioNTech compared with healthy people who got the same.  

Patients with myeloma and leukaemia are more predisposed to developing infections because of inherent immune defects related to their primary disease and also as a result of therapy. The mechanisms underlying the immunodeficiency in both could also impair the response to vaccination markedly. 

Other findings reported that senior patients with multiple myeloma were also likely to have far less robust responses to these vaccines. 

The key takeaway is that the first dose of the COVID-19 vaccines produces rather low levels of neutralizing antibody response among senior patients who have multiple myeloma.

We need more research and data to know the overall results of the second dose as well as the results among younger patients with multiple myeloma. But remember, it is vitally necessary for myeloma patients to get the both doses of the vaccine for a better response. 

Almost 75 days after the first vaccine dose, no patient developed COVID-19 infection during the period and no substantial differences were found associated with the vaccine. 

According to results, only 39.5% of patients with myeloma had a positive antibody-mediated response to the vaccine. 

For multiple myeloma after a single dose of the vaccine, antimyeloma therapy appeared to negatively affect the neutralizing antibody production, although study of more patients is needed to evaluate the effects of specific antimyeloma regimens on the immune responses of anti-COVID-19 vaccination, the researchers noted. But there was good response after both doses.

Get both vaccine shots, they will surely help